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Research

1997

Veterinary Microbiology

Coronavirus-challenge study comparing IgY against colostrum

Yutaka Ikemori, Masashi Ohta, Kouji Umeda, Faustino C. Icatlo, Masahiko Kuroki, Hideaki Yokoyama, Yoshikatsu Kodama, Passive protection of neonatal calves against bovine coronavirus-induced diarrhea by administration of egg yolk or colostrum antibody powder, Veterinary Microbiology, Volume 58, Issues 2–4, 1997, Pages 105-111, ISSN 0378-1135, https://doi.org/10.1016/S0378-1135(97)00144-2. (https://www.sciencedirect.com/science/article/pii/S0378113597001442)

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The protective effect of egg yolk and colostrum powders prepared from hens and cows vaccinated with inactivated bovine coronavirus (BCV) antigen was evaluated in a challenge model with a virulent BCV strain. Twenty three calves from BCV-free herds were randomly divided into control and several treatment groups. All calves were orally challenged with 1 × 109 TCID50 of the virulent Kakegawa strain of BCV at 24 to 36 h after birth. Calves in treatment groups received either egg yolk powder or cow colostrum containing BCV specific antibodies. Daily treatment with these antibody preparations started 6 h until 7 days post-challenge. Control calves which received no antibody had severe diarrhea and all died within 6 days after infection. In contrast, calves fed milk containing egg yolk or colostrum with neutralization titers of 1:2560 or 1:10 240 respectively all survived and had positive weight gain unlike the other treatment groups. These results indicate that the orally administered egg yolk and colostrum powders protected against BCV-induced diarrhea in neonatal calves and that the egg yolk used provided a higher degree of protection compared to colostrum powder on a titer basis. Treatment with whole egg yolk from immunized hens therefore provides a more efficacious alternative to the existing methods of specific passive protection against BCV.

Other Research

Calf Research

Development of an IgY-Based Treatment to Control Bovine Coronavirus Diarrhea in Dairy Calves

2023

Viruses

Bovine Coronavirus (BCoV) is a major pathogen associated with neonatal calf diarrhea. Standard practice dictates that to prevent BCoV diarrhea, dams should be immunized in the last stage of pregnancy…

Calf Research

Effect of immunized egg proteins on the performance and neonatal diarrhoea incidence in newborn calves

2021

Journal of Animal Physiology and Animal Nutrition

The aim of this study was to assess the effects of feeding immunized egg proteins (IEP) on the health and performance of newborn dairy calves. Sixty-four Holstein calves, both male…

Calf Research

A new passive immune strategy based on IgY antibodies as a key element to control neonatal calf diarrhea in dairy farms

2020

BMC Veterinary Research

Neonatal diarrhea remains one of the main causes of morbi-mortality in dairy calves under artificial rearing. It is often caused by infectious agents of viral, bacterial, or parasitic origin. Cows…

EgCel IgY: Technology

Explore our resources library in detail to learn how we are pusuing our vision to be the IgY technology that fills the gap left by the reduction of antibiotic and NSAID use in animal through continual innovation, learning, and challenging the status quo.